Author's response to reviews Title: Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis Authors:
نویسندگان
چکیده
Carsten P Bramlage ([email protected]) Bjoern Tampe ([email protected]) Michael Koziolek ([email protected]) Imad Maatouk ([email protected]) Jelena Bevanda ([email protected]) Peter Bramlage ([email protected]) Katharina Ahrens ([email protected]) Katharina Lange ([email protected]) Holger Schmid ([email protected]) Clemens Cohen ([email protected]) Matthias Kretzler ([email protected]) Gerhard A Müller ([email protected])
منابع مشابه
Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
BACKGROUND Bone Morphogenetic Protein (BMP)-7 is protective in different animal models of acute and chronic kidney disease. Its role in human kidneys, and in particular hypertensive nephrosclerosis, has thus far not been described. METHODS BMP-7 mRNA was quantified using real-time PCR and localised by immunostaining in tissue samples from normal and nephrosclerotic human kidneys. The impact o...
متن کاملکلونینگ و بررسی بیان ژن کد کننده BMP-2 انسانی در باکتری E. coli به منظور تولید یک داروی نوترکیب
Introduction & Objective: Bone morphogenetic proteins are a group of cytokines that belongs to superfamily TGFβ. These proteins play an important role in evolution of many of organs and tissues through germinal period followed by amending and rebuilding of bone tissue and car-tilage. The aim of this study was to clone and expression analysis of BMP-2 gene in E. coli bacteria. Materials & Method...
متن کاملThe expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter.
AIMS The expression of bone morphogenetic proteins (BMPs) was analysed in 47 osteosarcomas to determine differences in the expression of BMP subtypes and to correlate expression with response to chemotherapy, in addition to the disease free and overall survival of patients. METHODS The expression of BMPs was examined immunohistochemically in 47 biopsy specimens of osteosarcoma using commercia...
متن کاملRegulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton.
Bone morphogenetic proteins (BMPs) induce cartilage differentiation and morphogenesis. There are profound changes in the cytoskeletal architecture during the morphogenesis of cartilage. To investigate the possibility that morphogenetic signals such as BMPs may regulate chondrocyte phenotype by modulation of cytoskeletal protein expression, we determined whether the expression and distribution o...
متن کاملExpression of bone morphogenetic proteins, cartilage-derived morphogenetic proteins and related receptors in normal and osteoarthritic human articular cartilage.
Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs). These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7, BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining was carried out using polyclonal antibodies. The exp...
متن کامل